Soy is often a controversial topic online. Many claim it has feminizing effects or promotes cancers and other chronic diseases. However, our current evidence mainly highlights its protective role in various chronic diseases. 

This demonization of soy mainly stems from isoflavones, a phytoestrogen that has estrogen-like characteristics. Many animal studies have shown concerns about how soy affects hormones (1). However, when looking at human models, soy seems more of a hero than a villain. 

Breast cancer is one of the most common hormonal cancers in women. When soy isoflavones were tested against postmenopausal women, there were no significant changes in breast parenchyma. The tissue that composes the breast did not change between hormonal and fatty tissue (2).  

Soy has positive impacts on cardiovascular disease risk (CVR). Soy isoflavones significantly reduced CVR biomarkers in postmenopausal women (3). Well, what about men? The protective role is not gender-selective, as isoflavones reduce many cardiometabolic parameters in both men and women (4)

The many studies on soy in humans can make it confusing that soy is still controversial. So, as long as you eat whole forms of soy with a well-balanced diet, there is no need to worry about soy consumption. 

  1. Weber, K S et al. “Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats.” The Journal of endocrinology vol. 170,3 (2001): 591-9. doi:10.1677/joe.0.1700591

  2. Delmanto, Armando et al. “Effects of soy isoflavones on mammographic density and breast parenchyma in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial.” Menopause (New York, N.Y.) vol. 20,10 (2013): 1049-54. doi:10.1097/GME.0b013e3182850270

  3. Sathyapalan, T et al. “Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause.” Nutrition, metabolism, and cardiovascular diseases : NMCD vol. 28,7 (2018): 691-697. doi:10.1016/j.numecd.2018.03.007

  4. Tischmann, Lea et al. “Longer-term soy nut consumption improves vascular function and cardiometabolic risk markers in older adults: Results of a randomized, controlled cross-over trial.” Clinical nutrition (Edinburgh, Scotland) vol. 41,5 (2022): 1052-1058. doi:10.1016/j.clnu.2022.03.014

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